FAST DISSOLVING FILM OF DOMPERIDONE

Abstract The present investigation was undertaken with the objective of formulating mouth dissolving film s of the antiemetic drug Domperidone to enhance the convenience and compliance by the elderly and pediatric patients. Five formulae were prepared and were evaluated for their in vitro dissolution characteristics, in vitro disintegration time, and their physico-mechanical properties. College of Pharmacy and G. In view of high first pass metabolism and short plasma half-life it is an ideal candidate for rapid release drug delivery system. Please review our privacy policy. The weight of each film was found to be uniform. Dissolution test of films was performed using ml; phosphate buffer pH 6.

Domperidone is specific blocker of dopamine receptors D2 and D3 and is widely used to treat emesis. Materials and Methods Preparation of solid dispersion of Domperidone: All the formulation contained varied amount of polymer and hence thickness of each film was varied between the ranges of 0. Results and Discussions All the films were non-sticky, soft and semi-transparent. Film thicknesses were measured at five positions central and the four corners using the Digital Vernier Caliper and the mean thickness was calculated. It was measured manually by repeatedly folding a film at the same place till it broke. Both the solutions are sonicated and then casted in petridish.

All the formulation contained varied amount of polymer and hence thickness of each film was varied between the ranges of 0. All the films were non-sticky, soft and semi-transparent. Preparation of fast dissolving films: Please review our privacy policy. The selected solid dispersions were then utilized fklm the preparation of film by solvent casting method utilizing HPMC E15 as a film forming agent and PEG as plasticizer.

  DUPPATHAGE DUKA SINHALA FILM

Materials and Methods Preparation of solid dispersion of Domperidone: Folding endurance was measured manually and it was found to decrease with increase in the concentration of film forming polymer HPMC E The present investigation was undertaken with the objective of formulating mouth dissolving film s of the antiemetic drug Domperidone to enhance the convenience and compliance by the elderly and pediatric patients.

Domperidone is a drug tast choice in case of nausea and vomiting produced by chemotherapy, migraine headaches, food gast and viral infections.

Dissolution and Drug release: It causes dopamine receptor blockage both at the chemoreceptor trigger zone and at the gastric level. Preparation of solid dispersion of Domperidone: The weight of each film was found to be uniform. All the films were found to disintegrate within 70 sec.

College of Pharmacy and G. Properties such as homogeneity, diasolving, transparency and surface of the oral films were evaluated by visual inspection. It causes dopamine D2 and D3 receptor blockage both at the chemoreceptor trigger zone and at the gastric level. The drug release rate decreases as the concentration of the film forming agent HPMC E15 increases in the formulation.

National Center for Biotechnology InformationU. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.

Support Center Support Center. Surface of all the films were smooth except F1 formulation. Nil Conflict of Interest: Domperidone is specific blocker of dopamine receptors D2 and D3 and is widely used to treat emesis.

Among the prepared formulations F1, formulation showed minimum disintegration domperldone of seconds. Patel Institute of Pharmacy, P. Dissolution test of films was performed using ml; phosphate buffer pH 6. The surface pH of all the formulation was found to be in the range of 6. Five formulae were prepared and were evaluated for their in vitro dissolution characteristics, in vitro disintegration time, and their physico-mechanical properties.

  DRAGON CAVALIER DE BEURK SAISON 1 EPISODE 19

Formulation development and evaluation of mouth dissolving film of domperidone

Time required for the film to break was noted as in vitro disintegration time. Both the solutions are sonicated and then casted in petridish.

Film thicknesses were measured at five positions central and the four corners using the Digital Vernier Caliper and the mean thickness was calculated. Nagar, Anand, Gujarat, India. Abstract The present investigation was undertaken with the objective of formulating mouth dissolving film s of the antiemetic drug Domperidone to enhance the convenience and compliance by the elderly and pediatric patients.

This article has been cited by other articles in PMC. Table 1 Formulation of mouth dissolving film of domperidone.

Formulation development and evaluation of mouth dissolving film of domperidone

Formulation and evaluation of quick dissolving film of levocetirizine dihydrochloride. Footnotes Source of Support: It was measured manually by repeatedly folding a film at the same place till it broke. Results and Discussions All the films were non-sticky, soft and semi-transparent.